Simultaneous Spectrophotometric Determination of phenylephrine hydrochloride and Amoxicillin via Derivative Spectrophotometry

Aseel M Aljeboree, Abbas N Alshirifi


Simultaneous determination of phenylephrine hydrochloride and Amoxicillin via using derivative spectrophotometry is proposed in this work. The recommended derivative spectrophotometric method is suitable for the simultaneous analysis of univariate method due to its simplicity, low coast and short analysis time, nevertheless the effects of several instrument parameters on the derivative spectra causes a limitation in its application. The suggested method is simple, fast, inexpensive, and non-destructive and shows good linearity and sensitivity. The recommended method enables the estimation of the cited drugs either in the laboratory prepared as a single or in pharmaceutical formulations without prior separation.


Amoxicillin, Derivative spectrophotometry method, Determination, Phenylephrine hydrochloride, Spectrophotometry.

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