Synthesis and Biological Studies of Some Diazo Dyes As New Drugs

Main Article Content

Hanan M Ali1
Sanaa Qassem Badr
Asawer Salim Temma

Abstract

The novel azo dye (1) and diazo dye (2) was synthesized from two different drugs (paracetamol and cefpodoxime proxetil), followed by the purification and characterization of each. Then, the antimicrobial activities of (1) and (2) were screened in vitro towered Klebsiella spp., Aspergillus terreus and Candida glabrata infections by using different concentrations (0.008, 0.016 and 0.2 mg/mL) from each. Azo dye (1) is given high antimicrobial activity against gram-negative bacteria Klebsiella spp., good activity against Candida glabrata, and no activity against Aspergillus terreus. These activities were seemed to be better than that received by the diazo dye (2) using the same concentrations. The results were also showed that the synthetic dyes provided a non-toxic effect and didn’t show any hemolysis effect in the cells. Further, the results were indicated that each synthetic dye was treated the dull infection with Candida glabrata and Klebsiella spp. with good results, but the results of (1) still better than (2). Due to recommend these dyes as new drugs for disseminated infections with the two microorganisms.


How to cite this article: AL-Temimi, S.M. and AL-Rekabi, A.M. (2019). Synthesis and Biological Studies of Some Diazo Dyes As New Drugs. International Journal of Drug Delivery Technology, 9(4): 613-616.


Source of support: Nil.
Conflict of interest: None.

Article Details

Section
Research Article