Synthesis and Characterization of Orotic Acid Loaded Chitosan Inclusion Complex

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Abdelkader Hassani
Abul K. Azad
Hamid H. Enezei
Siti A. Hussain
ABM Helal Uddin


The current study aims to improve drug release properties of orotic acid loaded with chitosan inclusion complex (OA/CS).The OA/CS inclusion complex was synthesized using the freeze-drying technique. The characterization of inclusion OA/CS was carried out using Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffractometry (XRD), Differential Scanning Calorimetry (DSC), Zeta sizer, and Transmission Electron Microscopy (TEM). Furthermore, the size of OA/CS ranged between 58 nm and 200 nm, and the zeta potential was 30 mV. Thus, this study indicates that OA/CS has a promising future to develop a carrier for drug delivery systems further.

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